Bernd lobach biography of albert
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Abstract
Objective
This study aims to confirm the prognostic value of baseline serum neurofilament light chain (sNfL) for on-study disease activity and worsening in patients with relapsing MS (RMS).
Background
Previous post-hoc studies suggested that sNfL could be a prognostic biomarker in RMS. In the phase 3 ASCLEPIOS I/II trials in which ofatumumab demonstrated better efficacy outcomes than teriflunomide, treatment with ofatumumab also led to significantly reduced sNfL levels compared to teriflunomide treatment.
Design/Methods
In this study, we report protocol-planned analyses from the pooled ASCLEPIOS I/II trials (N=). Per protocol, patients were stratified by mittvärdet i en uppsättning data baseline sNfL levels ( pg/ml) into high (>median) and low (≤median) categories to prognosticate: annualized rate of new/enlarging T2 (neT2) lesions in year 1 and 2, annualized relapse rate, annual percentage change in whole brain (WB) and regional brain volume [thalamus, vit matter (WM), cortical gray ma
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3, SCIENTISTS AND ACADEMICS CALL FOR A FOSSIL FUEL NON-PROLIFERATION TREATY
Thousands of academics have urged governments to negotiate an international treaty to tackle the climate crisis at its source: fossil fuels.
We, the undersigned, call on governments around the world to adopt and implement a Fossil Fuel Non-Proliferation Treaty, as a matter of urgency, to protect the lives and livelihoods of present and future generations through a global, equitable phase out of fossil fuels in line with the scientific consensus to not exceed ºC of warming.
The fossil fuel system and its impacts are global and require a global solution. We call on governments to urgently commence negotiations to develop, adopt and implement a Fossil Fuel Non-Proliferation Treaty laying out a binding global plan to:
End new expansion of fossil fuel production in line with the best available science as outlined by the Intergovernmental Panel on Climate Change (IPCC) and the Unit
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Abstract
Atrial Fibrillation (AF) is a highly prevalent heart rhythm disturbance, often associated with underlying (cardio)vascular disease. Due to this the management of AF is often complex and current practice calls for a more comprehensive, multifactorial and patient-centred approach. Therefore an Integrated Chronic Care approach in AF was developed and implemented in terms of a nurse-led specialized outpatient clinic for patients with AF. A randomised controlled trial comparing the nurse-led approach with usual care demonstrated superiority in terms of cardiovascular hospitalization and death as well as cost-effectiveness in terms of Quality Adjusted Life Years (QALYs) and life years, in favour of the nurse-led approach. Implementing such approach can be difficult since daily practice can be persistent. To highlight the importance of integrated care wherein the nurse fulfils a significant role, and to provide a guide in developing and continuing such approach, this paper presen